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Natural products and peptides have historically been fantastic sources of medicines and agricultural products. In the Parkinson lab, we are interested in the discovery of novel bioactive natural products and peptides. Additionally, we develop improved derivatives and determine their mechanisms of action. We are particularly interested in molecules with antimicrobial, anticancer, antiamoebic, and antiphytopathogenic activities. We are also open to collaborations for screening other activities.

Related Publications:
Hostetler, M.A.; Smith, C.; Nelson, S.; Budimir, Z.; Modi, R.; Woolsey, I.; Frerk, A.; Baker, B.; Gantt, J., Parkinson, E.I.* "Synthetic Natural Product Inspired Cyclic Peptides. ACS Chem. Biol. 2021, 16, 11, 2604–2611. https://doi.org/10.1021/acschembio.1c00641

Modi, R.; McKee, N.; Zhang, N.; Alwali, A.; Nelson, S.; Lohar, A.; Ostafe, R.; Zhang, D.D.; Parkinson, E.I* "Stapled Peptides as Direct Inhibitors of Nrf2-sMAF Transcription Factors" J. Med. Chem. 2023, 66, 6184–6192. https://doi.org/10.1021/acs.jmedchem.2c02037

Nelson, S.; Harris, T.J.; Muli, C.S.; Maresh, M.E.; Baker, B.; Smith, C.; Neumann, C.; Trader, D.J.; Parkinson, E.I.* "Discovery and Development of Cyclic Peptide Proteasome   Stimulators ChemBioChem. 2024, 25, e202300671. https://doi.org/10.1002/cbic.202300671

Amir Y Alwali, Diane Santos, César Aguilar, Audrey Birch, Lorena Rodriguez-Orduña, Carson B Roberts, Ramya Modi, Cuauhtemoc Licona-Cassani, Elizabeth I Parkinson* "Discovery of Streptomyces species CS-62, a novel producer of the Acinetobacter baumannii selective antibiotic factumycin" J. Ind. Microbiol. Biotechnol. 2024, 51 kuae014. https://doi.org/10.1093/jimb/kuae014

Noah M. Moriarty, Annaleigh M. Benton, Lauren E. Gartenhaus, Andrew R. Nelson, Haley A. Harper, Carli J. McMahan, Bennett D. Elzey, Jason A. Hanna*, and Elizabeth I. Parkinson* "Design, Synthesis, and Evaluation of Trihalomethyl Ketone Derivatives of Neocarzilin A as Improved Antimetastatic Agents" ACS Bio & Med Chem Au. 2024, 4, 6, 331–341, https://doi.org/10.1021/acsbiomedchemau.4c00087

Chenyang Lu, Samantha Nelson, Gabriela Coy, Chris Neumann, Elizabeth I. Parkinson*, Christopher A. Rice* "Cyclic Peptide Natural Product Inspired Inhibitors of the Free-Living Amoeba Balamuthia mandrillaris" J. Nat. Prod. 2025, 88, 274-281, https://doi.org/10.1021/acs.jnatprod.4c00834
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© 2020 by Elizabeth Parkinson.

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