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Many natural product biosynthetic gene clusters (BGCs) are not produced under standard laboratory conditions. To access natural products from these silent BGCs, we use bioinformatics softwares to predict the natural product structure and then chemically synthesize molecule. We then test these natural product inspired natural products for potential bioactivities. For more details about bioactivity screening, please see the bioactivities page. 

Related Publications:
Hostetler, M.A.; Smith, C.; Nelson, S.; Budimir, Z.; Modi, R.; Woolsey, I.; Frerk, A.; Baker, B.; Gantt, J., Parkinson, E.I.* "Synthetic Natural Product Inspired Cyclic Peptides. ACS Chem. Biol. 2021, 16, 11, 2604–2611. https://doi.org/10.1021/acschembio.1c00641

Nelson, S.; Harris, T.J.; Muli, C.S.; Maresh, M.E.; Baker, B.; Smith, C.; Neumann, C.; Trader, D.J.; Parkinson, E.I.* "Discovery and Development of Cyclic Peptide Proteasome   Stimulators ChemBioChem. 2024, 25, e202300671. https://doi.org/10.1002/cbic.202300671

Samantha Nelson and Elizabeth I. Parkinson* "Synthetic-bioinformatic natural product-inspired peptides" Nat. Prod. Rep. 2025, 42, 50-66, https://doi.org/10.1039/D4NP00043A

Chenyang Lu, Samantha Nelson, Gabriela Coy, Chris Neumann, Elizabeth I. Parkinson*, Christopher A. Rice* "Cyclic Peptide Natural Product Inspired Inhibitors of the Free-Living Amoeba Balamuthia mandrillaris" J. Nat. Prod. 2025, 88, 274-281, https://doi.org/10.1021/acs.jnatprod.4c00834

Gabriela Coy, Elliot Brajkovich, and Elizabeth I. Parkinson*. "Bioinformatics guided synthesis of natural product cyclic peptides" Methods Enzymol. 2025, ASAP, https://doi.org/10.1016/bs.mie.2025.03.003
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© 2020 by Elizabeth Parkinson.

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