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Natural products are produced by biosynthetic enzymes often encoded in biosynthetic gene clusters. These biosynthetic enzymes often perform unique chemistries that have the potential to be biocatalysts. We use bioinformatics to identify potentially interesting biosynthetic enzymes and then explore their activities and substrate scopes. We also use mutagenesis and evolution strategies to expand their utility as biocatalysts.

Related Publications:
Parkinson, E.I.*; Lakkis, H.G.; Alwali, A.A.; Metcalf, M.E.M.; Modi, R.; Metcalf, W.W.* "An Unusual Oxidative Rearrangement Catalyzed by a Divergent Member of the 2-Oxoglutarate-Dependent Dioxygenase Superfamily during Biosynthesis of Dehydrofosmidomycin" Angew. Chem. Int. Ed. 2022, 61(30):e202206173. https://doi.org/10.1002/anie.202206173 

Budimir, Z.L.; Patel, R.S.; Eggly, A.; Evans, C.N.; Rondon-Cordero, H.M.; Adams, J.J.; Das, C.; Parkinson, E.I.* "Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase" Nature Chem. Biol.  2024, 20, 120–128. https://doi.org/10.1038/s41589-023-01495-z 

Weimao Zhong#, Zachary L. Budimir#, Lucas O. Johnson, Elizabeth I. Parkinson*, Vinayak Agarwal*. "Activity and Biocatalytic Potential of an Indolylamide Generating Thioesterase" Org. Lett. 2024,  26, 43, 9378–9382, https://doi.org/10.1021/acs.orglett.4c03648 
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© 2020 by Elizabeth Parkinson.

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