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Many natural product biosynthetic gene clusters (BGCs) are not produced under standard laboratory conditions. We are interested in the processes that regulate natural product production. In particular, we are interested in small molecule signals such as quorum sensing agents and their abilities to induce production of natural products. Given the low titers for many quorum sensing molecules, we develop synthetic routes to these molecules and assays to test for their activities. We also explore the application of quorum sensing systems in synthetic biology.

Related Publications:
Wilbanks, L.E.; Hennigan, H.E.; Martinez-Brokaw, C.D.; Lakkis, H.; Thormann, S.; Eggly, A.S.; Buechel, G.; Parkinson, E.I.* "Synthesis of Gamma-Butyrolactone Hormones Enables Understanding of Natural Product Induction" ACS Chem. Biol. 2023, 18, 1624-1631.. https://doi.org/10.1021/acschembio.3c00241

Alwali, A.Y.; Parkinson, E.I.* "Small Molecule Inducers of Actinobacteria Natural Product Biosynthesis" J. Ind. Microbiol. Biotechnol. 2023, 50, kuad019. https://doi.org/10.1093/jimb/kuad019  

Alyssa S. Eggly, Namuunzul Otgontseren, Carson B. Roberts, Amir Y. Alwali, Haylie E. Hennigan, and Elizabeth I. Parkinson* "A Diels–Alder probe for discovery of natural products containing furan moieties" Beilstein J. Org. Chem. 2024, 20, 1001-1010. https://doi.org/10.3762/bjoc.20.88

Haylie E. Hennigan, Namuunzul Otgontseren, and Elizabeth I. Parkinson* "Rapid Access to Enantiopure Protected (R)-Paraconyl Alcohol" Org. Synth. 2025, 102, 251. DOI: 10.15227/orgsyn.102.0251
 
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© 2020 by Elizabeth Parkinson.

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