publications

Parkinson Lab

25. Wilbanks, L.E.; Brajkovich, E.N.; Baumgart, L.; Zhang, Y.; Grosjean, N.; Blaby, I.; Parkinson, E.I.* “DAP-seq Reveals Cluster-Situated Regulator Control of Numerous Streptomyces Natural Product Biosynthetic Genes” J. Nat. Prod. 2026. ASAP. https://doi.org/10.1021/acs.jnatprod.5c01605

24. Samal, S.†; Xiao, S.†; Nelson, S.; Kolhe, O.; Khan, H.F.; Matin, M.H.; Lee, W.J.; Ahmed, M.; Wang, D.; Wang, T.; Pikes, T.; Scott, A.N.; Rodriguez, A.; Olson, M.R.; Deng, Q.; Parkinson, E.I.; Rochet, J.C.; Jayant, K.*; Mei, J.* “Blood-Catalyzed Polymerization Creates Conductive Polymer in Live Zebrafish” Science. 2026. 392, 54 †co-first authors. DOI: 10.1126/science.adu5500

23. Zhang, Z.; Liu, Y.K.; Luo, M.W; Evans, C.N.; Qu, Z.; Xue, F.; Zhang, Z.Y.; Parkinson, E.I.; Bardeesy, N.; Tao, W.A. “Discovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG”. Nat. Chem. 2026. ASAP. https://doi.org/10.1038/s41557-026-02093-x

22. Hennigan, H.E.; Frias-Gomez, M.; Castator, K.G.; Wilbanks, L.E.; Zu, C.; Sanders, G.; Parkinson, E.I.* “Enantioselective Synthesis of Antibiotic Inducing Gamma-Butenolides from Streptomyces rochei and Derivatives” Org. Biomol. Chem. 2026. 24, 2069-2074. https://doi.org/10.1039/D5OB01862E

21. Paisley L. Jeannette,† Zachary L. Budimir,† Lucas O. Johnson, Elizabeth I. Parkinson* “Biocatalytic Tetrapeptide Macrocyclization by Cryptic Penicillin-binding Protein-type Thioesterases” Biochemistry. 2026. 65, 486–499. †co-first authors. https://doi.org/10.1021/acs.biochem.5c00758

20. Zachary L. Budimir and Elizabeth I. Parkinson* “Discovery and development of penicillin-binding protein-type thioesterases as biocatalysts” Curr. Opin. Biotechnol. 2026. 97, 103417. https://doi.org/10.1016/j.copbio.2025.103417

19. Kylie G. Castator, Manuela Frias-Gomez, Lauren E. Wilbanks, and Elizabeth I. Parkinson* "Diastereoselective, Diversifiable Synthesis and Biological Evaluation of the Virginiamycin Inducers, the Virginiae Butanolides" ChemBioChem. 2025, 26, e202500386. https://doi.org/10.1002/cbic.202500386

18. Haylie E. Hennigan, Namuunzul Otgontseren, and Elizabeth I. Parkinson* "Rapid Access to Enantiopure Protected (R)-Paraconyl Alcohol" Org. Synth. 2025, 102, 251. DOI: 10.15227/orgsyn.102.0251

17. Gabriela Coy, Elliot Brajkovich, and Elizabeth I. Parkinson*. "Bioinformatics guided synthesis of natural product cyclic peptides" Methods Enzymol. 2025, 26, e202500386. https://doi.org/10.1016/bs.mie.2025.03.003

16. Chenyang Lu, Samantha Nelson, Gabriela Coy, Chris Neumann, Elizabeth I. Parkinson*, Christopher A. Rice* "Cyclic Peptide Natural Product Inspired Inhibitors of the Free-Living Amoeba Balamuthia mandrillaris" J. Nat. Prod. 2025, 88, 274-281, https://doi.org/10.1021/acs.jnatprod.4c00834

15. Samantha Nelson and Elizabeth I. Parkinson* "Synthetic-bioinformatic natural product-inspired peptides" Nat. Prod. Rep. 2025, 42, 50-66, https://doi.org/10.1039/D4NP00043A

14. Noah M. Moriarty, Annaleigh M. Benton, Lauren E. Gartenhaus, Andrew R. Nelson, Haley A. Harper, Carli J. McMahan, Bennett D. Elzey, Jason A. Hanna*, and Elizabeth I. Parkinson* "Design, Synthesis, and Evaluation of Trihalomethyl Ketone Derivatives of Neocarzilin A as Improved Antimetastatic Agents" ACS Bio & Med Chem Au. 2024, 4, 6, 331–341, https://doi.org/10.1021/acsbiomedchemau.4c00087

13. Weimao Zhong#, Zachary L. Budimir#, Lucas O. Johnson, Elizabeth I. Parkinson*, Vinayak Agarwal*. "Activity and Biocatalytic Potential of an Indolylamide Generating Thioesterase" Org. Lett. 2024, 26, 43, 9378–9382, https://doi.org/10.1021/acs.orglett.4c03648

12. Annaleigh Benton, Noah M. Moriarty, Emma Terwilliger, Bozhi Liu, Ant Murphy, Hannah Maluvac, Mae Shu, Lauren E. Gartenhaus, Nimod D. Janson, Claire M. Pfeffer, Sagar M. Utturkar, Elizabeth I. Parkinson, Nadia A. Lanman, Jason A. Hanna* "miR-497 target gene regulatory network in angiosarcoma" Mol Cancer Res. 2024, 22, 879–890., https://doi.org/10.1158/1541-7786.MCR-23-1075

11. César Aguilar, Amir Alwali, Madeline Mair, Lorena Rodriguez-Orduña, Haydeé Contreras-Peruyero, Ramya Modi, Carson Roberts, Nelly Sélem-Mojica, Cuauhtemoc Licona-Cassani, and Elizabeth I. Parkinson* "Actinomycetota bioprospecting from ore-forming environments" Microbial Genomics. 2024, 10, 10:001253. https://doi.org/10.1099/mgen.0.001253

10. Alyssa S. Eggly, Namuunzul Otgontseren, Carson B. Roberts, Amir Y. Alwali, Haylie E. Hennigan, and Elizabeth I. Parkinson* "A Diels–Alder probe for discovery of natural products containing furan moieties" Beilstein J. Org. Chem. 2024, 20, 1001-1010. https://doi.org/10.3762/bjoc.20.88

9. Amir Y Alwali, Diane Santos, César Aguilar, Audrey Birch, Lorena Rodriguez-Orduña, Carson B Roberts, Ramya Modi, Cuauhtemoc Licona-Cassani, Elizabeth I Parkinson* "Discovery of Streptomyces species CS-62, a novel producer of the Acinetobacter baumannii selective antibiotic factumycin" J. Ind. Microbiol. Biotechnol. 2024, 51 kuae014. https://doi.org/10.1093/jimb/kuae014

8. Budimir, Z.L.; Patel, R.S.; Eggly, A.; Evans, C.N.; Rondon-Cordero, H.M.; Adams, J.J.; Das, C.; Parkinson, E.I.* "Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase" Nature Chem. Biol. 2024, 20, 120–128. https://doi.org/10.1038/s41589-023-01495-z

7. Nelson, S.; Harris, T.J.; Muli, C.S.; Maresh, M.E.; Baker, B.; Smith, C.; Neumann, C.; Trader, D.J.; Parkinson, E.I.* "Discovery and Development of Cyclic Peptide Proteasome Stimulators ChemBioChem. 2024, 25, e202300671. https://doi.org/10.1002/cbic.202300671

6. Alwali, A.Y.; Parkinson, E.I.* "Small Molecule Inducers of Actinobacteria Natural Product Biosynthesis" J. Ind. Microbiol. Biotechnol. 2023, 50, kuad019. https://doi.org/10.1093/jimb/kuad019

5. Wilbanks, L.E.; Hennigan, H.E.; Martinez-Brokaw, C.D.; Lakkis, H.; Thormann, S.; Eggly, A.S.; Buechel, G.; Parkinson, E.I.* "Synthesis of Gamma-Butyrolactone Hormones Enables Understanding of Natural Product Induction" ACS Chem. Biol. 2023, 18, 1624-1631.. https://doi.org/10.1021/acschembio.3c00241

4. Modi, R.; McKee, N.; Zhang, N.; Alwali, A.; Nelson, S.; Lohar, A.; Ostafe, R.; Zhang, D.D.; Parkinson, E.I* "Stapled Peptides as Direct Inhibitors of Nrf2-sMAF Transcription Factors" J. Med. Chem. 2023, 66, 6184–6192. https://doi.org/10.1021/acs.jmedchem.2c02037

3. Parkinson, E.I.*; Lakkis, H.G.; Alwali, A.A.; Metcalf, M.E.M.; Modi, R.; Metcalf, W.W.* "An Unusual Oxidative Rearrangement Catalyzed by a Divergent Member of the 2-Oxoglutarate-Dependent Dioxygenase Superfamily during Biosynthesis of Dehydrofosmidomycin" Angew. Chem. Int. Ed. 2022, 61(30):e202206173. https://doi.org/10.1002/anie.202206173

2. Hostetler, M.A.; Smith, C.; Nelson, S.; Budimir, Z.; Modi, R.; Woolsey, I.; Frerk, A.; Baker, B.; Gantt, J., Parkinson, E.I.* "Synthetic Natural Product Inspired Cyclic Peptides. ACS Chem. Biol. 2021, 16, 11, 2604–2611. https://doi.org/10.1021/acschembio.1c00641

1. Schorn MA, Verhoeven S, Ridder L, Huber F, Acharya DD, Aksenov AA, Aleti G, Moghaddam JA, Aron AT, Aziz S, Bauermeister A, Bauman KD, Baunach M, Beemelmanns C, Beman JM, Berlanga-Clavero MV, Blacutt AA, Bode HB, Boullie A, Brejnrod A, Bugni TS, Calteau A, Cao L, Carrión VJ, Castelo-Branco R, Chanana S, Chase AB, Chevrette MG, Costa-Lotufo LV, Crawford JM, Currie CR, Cuypers B, Dang T, de Rond T, Demko AM, Dittmann E, Du C, Drozd C, Dujardin JC, Dutton RJ, Edlund A, Fewer DP, Garg N, Gauglitz JM, Gentry EC, Gerwick L, Glukhov E, Gross H, Gugger M, Guillén Matus DG, Helfrich EJN, Hempel BF, Hur JS, Iorio M, Jensen PR, Kang KB, Kaysser L, Kelleher NL, Kim CS, Kim KH, Koester I, König GM, Leao T, Lee SR, Lee YY, Li X, Little JC, Maloney KN, Männle D, Martin H C, McAvoy AC, Metcalf WW, Mohimani H, Molina-Santiago C, Moore BS, Mullowney MW, Muskat M, Nothias LF, O'Neill EC, Parkinson EI, Petras D, Piel J, Pierce EC, Pires K, Reher R, Romero D, Roper MC, Rust M, Saad H, Saenz C, Sanchez LM, Sørensen SJ, Sosio M, Süssmuth RD, Sweeney D, Tahlan K, Thomson RJ, Tobias NJ, Trindade-Silva AE, van Wezel GP, Wang M, Weldon KC, Zhang F, Ziemert N, Duncan KR, Crüsemann M, Rogers S, Dorrestein PC, Medema MH, van der Hooft JJJ. “A community resource for paired genomic and metabolomic data mining.” Nat Chem Biol. 2021. 17, 363-368. https://doi.org/10.1038/s41589-020-00724-z

Prior to Parkinson Lab

13. Lundberg, A.P.; Boudreau, M.W.; Selting, K.A.; Chatkewitz, L.E.; Samuelson, J.; Francis, J.M.; Parkinson, E.I.; Barger, A.M.; Hergenrother, P.J.; Fan, T.M. Neoplasia. 2021, 23, 811-822. https://doi.org/10.1016/j.neo.2021.06.008

12. Navarro-Muñoz, J.C.; Selem-Mojica, N.; Mullowney, M.W.; Kautsar, S.; Tryon, J.H.; Parkinson, E.I.; De Los Santos, E.L.C.; Yeong, M.; Cruz-Morales, P.; Abubucker, S.; Roeters, A.; Lokhorst, W.; Fernandez-Guerra, A.; Cappelini, L.T.D; Thomson, R.J.; Metcalf, W.W.; Kelleher, N.L.; Barona-Gomez, F.; Medema, M.H, “A computational framework to explore large-scale biosynthetic diversity.” Nat. Chem. Biol. 2020, 16, 60. doi: 10.1038/s41589-019-0400-9.

11. Parkinson, E.I.; Erb, A.; Eliot, A.C.; Ju, K.; Metcalf, W.W. “Fosmidomycin biosynthesis diverges from related phosphonate natural products.” Nat. Chem. Biol. 2019 . 10.1038/s41589-019-0343-1. ASAP

10. Parkinson, E.I.; Goering, A.W.; Tryon, J.H.; Ju, K.; McClure, R.A.; Kemball, J.D.; Zhukovsky, S.; Thomson, R.J.; Kelleher, N.L.; Metcalf, W.W. 2018, “Discovery of the Tyrobetaine Natural Product Family and Their Biosynthesis Using Metabologenomics.” ACS Chem. Biol. 13, 1029-1037 DOI: 10.1021/acschembio.7b01089.

9. Lee, HY.; Parkinson, E.I.; Granchi, C.; Panigrahy, D.; Seth, P.; Minutolo, F.; Hergenrother, P.J. ACS Chem. Biol. 2017, “Reactive Oxygen Species Synergize to Potently and Selectively Induce Cancer Cell Death”. 12, 1416. DOI: 10.1021/acschembio.7b00015

8. Lundberg, A.P.; Francis, J.M.; Pojaka, M.; Parkinson, E.I.; Wycisloc, K.; Rosold, T.J.; Browne, M.E.; Londond, C.A.; Dirikoluf, L.; Hergenrother, P.J.; Fan, T.M. Invest. New Drugs. 2017, “Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ) in the domestic felid species.” 35, 134. DOI:10.1007/s10637-016-0414-z.

7. Parkinson, E.I.; Hergenrother, P.J. Acc. Chem. Res. 2015, “Deoxynyboquinones as Personalized Cancer Therapeutics.” 48, 2715. DOI: 10.1021/acs.accounts.5b00365

6. Parkinson, E.I.; Bair, J.S.; Nakamura, B.A.; Lee, H.Y.; Kuttab, H.K.; Southgate, E.S.; Lau, G.W.; Hergenrother, P.J. Nat. Commun. 2015, “Deoxynybomycins Inhibit Mutant DNA Gyrase and Rescue Mice Infected with Fluoroquinolone-Resistant Bacteria.” 6, 6947. DOI: 10.1038/ncomms7947

5. Granger, B. A.; Jewett, I, T.; Butler, J. D.; Hua, B.; Knezevic, C. E.; Parkinson, E.I.; Hergenrother, P. J.; Martin, S. F J. Am. Chem. Soc. 2013, “Synthesis of (±)-Actinophyllic Acid and Analogs: Applications of Cascade Reactions and Diverted Total Synthesis.” 135,12984-12986. DOI: 10.1021/ja4070206

4. Parkinson, E.I.; Bair, J.S.; Cismesia, M. Hergenrother, P.J. ACS Chem. Biol. 2013, “Efficient NQO1 Substrates are Potent and Selective Anticancer Agents.” 8, 2173-2183, DOI: 10.1021/cb4005832

3. Huang, X.; Dong, Y.; Bey, E.A.; Kilgore, J.A.; Bair, J.S.; Li, L.; Patel, M.; Parkinson, E.I.; Wang, Y.; Williams, N.S.; Gao, J.; Hergenrother, P.J.; Boothman, D.A. Cancer Res. 2012, “An NQO1 Substrate with Potent Antitumor Activity that Selectively Kills by PARP1-Induced Programmed Necrosis.” 72, 3038-3047, DOI: 10.1158/0008-5472.CAN-11-3135.

2. Parkinson, E.I.; Hergenrother, P.J. ChemMedChem. 2011, “Runaway ROS as a Selective Anticancer Strategy.” 6, 1957-1959, DOI: 10.1002/cmdc.201100381.

1. Parkinson, E.I.; Hatfield, J.M.; Tsurkan, L.; Hyatt, J.L.; Edwards, C.C.; Hicks, L.D.; Yan, B.; Potter, P.M. Bioorg. Med. Chem. 2011, “Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.” 29, 4635-4643, DOI: 10.1016/j.bmc.2011.06.012.

The Parkinson Lab

Parkinson Lab

Prior to Parkinson Lab