Parkinson Lab

Coming soon!

Prior to Parkinson Lab

12. Navarro-Muñoz, J.C.; Selem-Mojica, N.; Mullowney, M.W.; Kautsar, S.; Tryon, J.H.; Parkinson, E.I.; De Los Santos, E.L.C.; Yeong, M.; Cruz-Morales, P.; Abubucker, S.; Roeters, A.; Lokhorst, W.; Fernandez-Guerra, A.; Cappelini, L.T.D; Thomson, R.J.; Metcalf, W.W.; Kelleher, N.L.; Barona-Gomez, F.; Medema, M.H, “A computational framework to explore large-scale biosynthetic diversity.” Nat. Chem. Biol. 2020, 16, 60. doi: 10.1038/s41589-019-0400-9.

11. Parkinson, E.I.; Erb, A.; Eliot, A.C.; Ju, K.; Metcalf, W.W. “Fosmidomycin biosynthesis diverges from related phosphonate natural products.” Nat. Chem. Biol. 2019 . 10.1038/s41589-019-0343-1. ASAP

10. Parkinson, E.I.; Goering, A.W.; Tryon, J.H.; Ju, K.; McClure, R.A.; Kemball, J.D.; Zhukovsky, S.; Thomson, R.J.; Kelleher, N.L.; Metcalf, W.W. 2018, “Discovery of the Tyrobetaine Natural Product Family and Their Biosynthesis Using Metabologenomics.” ACS Chem. Biol. 13, 1029-1037 DOI: 10.1021/acschembio.7b01089.


9. Lee, HY.; Parkinson, E.I.; Granchi, C.; Panigrahy, D.; Seth, P.; Minutolo, F.; Hergenrother, P.J. ACS Chem. Biol. 2017, “Reactive Oxygen Species Synergize to Potently and Selectively Induce Cancer Cell Death”. 12, 1416. DOI: 10.1021/acschembio.7b00015 


8. Lundberg, A.P.; Francis, J.M.; Pojaka, M.; Parkinson, E.I.; Wycisloc, K.; Rosold, T.J.; Browne, M.E.; Londond, C.A.; Dirikoluf, L.; Hergenrother, P.J.; Fan, T.M. Invest. New Drugs. 2017, “Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ) in the domestic felid species.” 35, 134. DOI:10.1007/s10637-016-0414-z.


7. Parkinson, E.I.; Hergenrother, P.J. Acc. Chem. Res. 2015, “Deoxynyboquinones as Personalized Cancer Therapeutics.” 48, 2715. DOI: 10.1021/acs.accounts.5b00365


6. Parkinson, E.I.; Bair, J.S.; Nakamura, B.A.; Lee, H.Y.; Kuttab, H.K.; Southgate, E.S.; Lau, G.W.; Hergenrother, P.J.  Nat. Commun. 2015, “Deoxynybomycins Inhibit Mutant DNA Gyrase and Rescue Mice Infected with Fluoroquinolone-Resistant Bacteria.” 6, 6947. DOI: 10.1038/ncomms7947


5. Granger, B. A.; Jewett, I, T.; Butler, J. D.; Hua, B.; Knezevic, C. E.; Parkinson, E.I.; Hergenrother, P. J.; Martin, S. F J. Am. Chem. Soc. 2013, “Synthesis of (±)-Actinophyllic Acid and Analogs:  Applications of Cascade Reactions and Diverted Total Synthesis.” 135,12984-12986.  DOI: 10.1021/ja4070206


4. Parkinson, E.I.; Bair, J.S.; Cismesia, M. Hergenrother, P.J. ACS Chem. Biol. 2013, “Efficient NQO1 Substrates are Potent and Selective Anticancer Agents.” 8, 2173-2183, DOI: 10.1021/cb4005832


3. Huang, X.; Dong, Y.; Bey, E.A.; Kilgore, J.A.; Bair, J.S.; Li, L.; Patel, M.; Parkinson, E.I.; Wang, Y.; Williams, N.S.; Gao, J.; Hergenrother, P.J.; Boothman, D.A. Cancer Res. 2012, “An NQO1 Substrate with Potent Antitumor Activity that Selectively Kills by PARP1-Induced Programmed Necrosis.” 72, 3038-3047, DOI: 10.1158/0008-5472.CAN-11-3135.


2. Parkinson, E.I.; Hergenrother, P.J. ChemMedChem. 2011, “Runaway ROS as a Selective Anticancer Strategy.” 6, 1957-1959, DOI: 10.1002/cmdc.201100381.


1. Parkinson, E.I.; Hatfield, J.M.; Tsurkan, L.; Hyatt, J.L.; Edwards, C.C.; Hicks, L.D.; Yan, B.; Potter, P.M. Bioorg. Med. Chem. 2011, “Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.” 29, 4635-4643, DOI: 10.1016/j.bmc.2011.06.012.