Parkinson Lab

16. Parkinson, E.I.*; Lakkis, H.G.; Alwali, A.A.; Metcalf, M.E.M.; Modi, R.; Metcalf, W.W.* "An Unusual Oxidative Rearrangement Catalyzed by a Divergent Member of the 2-Oxoglutarate-Dependent Dioxygenase Superfamily during Biosynthesis of Dehydrofosmidomycin" Angew. Chem. Int. Ed. 2022, ASAP. https://doi.org/10.1002/anie.20220617

15. Hostetler, M.A.; Smith, C.; Nelson, S.; Budimir, Z.; Modi, R.; Woolsey, I.; Frerk, A.; Baker, B.; Gantt, J., Parkinson, E.I.* "Synthetic Natural Product Inspired Cyclic Peptides. ACS Chem. Biol. 2021, 16, 11, 2604–2611. https://doi.org/10.1021/acschembio.1c00641

14. Schorn MA, Verhoeven S, Ridder L, Huber F, Acharya DD, Aksenov AA, Aleti G, Moghaddam JA, Aron AT, Aziz S, Bauermeister A, Bauman KD, Baunach M, Beemelmanns C, Beman JM, Berlanga-Clavero MV, Blacutt AA, Bode HB, Boullie A, Brejnrod A, Bugni TS, Calteau A, Cao L, Carrión VJ, Castelo-Branco R, Chanana S, Chase AB, Chevrette MG, Costa-Lotufo LV, Crawford JM, Currie CR, Cuypers B, Dang T, de Rond T, Demko AM, Dittmann E, Du C, Drozd C, Dujardin JC, Dutton RJ, Edlund A, Fewer DP, Garg N, Gauglitz JM, Gentry EC, Gerwick L, Glukhov E, Gross H, Gugger M, Guillén Matus DG, Helfrich EJN, Hempel BF, Hur JS, Iorio M, Jensen PR, Kang KB, Kaysser L, Kelleher NL, Kim CS, Kim KH, Koester I, König GM, Leao T, Lee SR, Lee YY, Li X, Little JC, Maloney KN, Männle D, Martin H C, McAvoy AC, Metcalf WW, Mohimani H, Molina-Santiago C, Moore BS, Mullowney MW, Muskat M, Nothias LF, O'Neill EC, Parkinson EI, Petras D, Piel J, Pierce EC, Pires K, Reher R, Romero D, Roper MC, Rust M, Saad H, Saenz C, Sanchez LM, Sørensen SJ, Sosio M, Süssmuth RD, Sweeney D, Tahlan K, Thomson RJ, Tobias NJ, Trindade-Silva AE, van Wezel GP, Wang M, Weldon KC, Zhang F, Ziemert N, Duncan KR, Crüsemann M, Rogers S, Dorrestein PC, Medema MH, van der Hooft JJJ. “A community resource for paired genomic and metabolomic data mining.” Nat Chem Biol. 2021. 17, 363-368. doi: 10.1038/s41589-020-00724-z. PubMed PMID: 33589842.

Prior to Parkinson Lab

13. Lundberg, A.P.; Boudreau, M.W.; Selting, K.A.; Chatkewitz, L.E.; Samuelson, J.; Francis, J.M.; Parkinson, E.I.; Barger, A.M.; Hergenrother, P.J.; Fan, T.M. Neoplasia. 2021, 23, 811-822. https://doi.org/10.1016/j.neo.2021.06.008

12. Navarro-Muñoz, J.C.; Selem-Mojica, N.; Mullowney, M.W.; Kautsar, S.; Tryon, J.H.; Parkinson, E.I.; De Los Santos, E.L.C.; Yeong, M.; Cruz-Morales, P.; Abubucker, S.; Roeters, A.; Lokhorst, W.; Fernandez-Guerra, A.; Cappelini, L.T.D; Thomson, R.J.; Metcalf, W.W.; Kelleher, N.L.; Barona-Gomez, F.; Medema, M.H, “A computational framework to explore large-scale biosynthetic diversity.” Nat. Chem. Biol. 2020, 16, 60. doi: 10.1038/s41589-019-0400-9.

11. Parkinson, E.I.; Erb, A.; Eliot, A.C.; Ju, K.; Metcalf, W.W. “Fosmidomycin biosynthesis diverges from related phosphonate natural products.” Nat. Chem. Biol. 2019 . 10.1038/s41589-019-0343-1. ASAP

10. Parkinson, E.I.; Goering, A.W.; Tryon, J.H.; Ju, K.; McClure, R.A.; Kemball, J.D.; Zhukovsky, S.; Thomson, R.J.; Kelleher, N.L.; Metcalf, W.W. 2018, “Discovery of the Tyrobetaine Natural Product Family and Their Biosynthesis Using Metabologenomics.” ACS Chem. Biol. 13, 1029-1037 DOI: 10.1021/acschembio.7b01089.

 

9. Lee, HY.; Parkinson, E.I.; Granchi, C.; Panigrahy, D.; Seth, P.; Minutolo, F.; Hergenrother, P.J. ACS Chem. Biol. 2017, “Reactive Oxygen Species Synergize to Potently and Selectively Induce Cancer Cell Death”. 12, 1416. DOI: 10.1021/acschembio.7b00015 

 

8. Lundberg, A.P.; Francis, J.M.; Pojaka, M.; Parkinson, E.I.; Wycisloc, K.; Rosold, T.J.; Browne, M.E.; Londond, C.A.; Dirikoluf, L.; Hergenrother, P.J.; Fan, T.M. Invest. New Drugs. 2017, “Pharmacokinetics and derivation of an anticancer dosing regimen for the novel anti-cancer agent isobutyl-deoxynyboquinone (IB-DNQ) in the domestic felid species.” 35, 134. DOI:10.1007/s10637-016-0414-z.

 

7. Parkinson, E.I.; Hergenrother, P.J. Acc. Chem. Res. 2015, “Deoxynyboquinones as Personalized Cancer Therapeutics.” 48, 2715. DOI: 10.1021/acs.accounts.5b00365

 

6. Parkinson, E.I.; Bair, J.S.; Nakamura, B.A.; Lee, H.Y.; Kuttab, H.K.; Southgate, E.S.; Lau, G.W.; Hergenrother, P.J.  Nat. Commun. 2015, “Deoxynybomycins Inhibit Mutant DNA Gyrase and Rescue Mice Infected with Fluoroquinolone-Resistant Bacteria.” 6, 6947. DOI: 10.1038/ncomms7947

 

5. Granger, B. A.; Jewett, I, T.; Butler, J. D.; Hua, B.; Knezevic, C. E.; Parkinson, E.I.; Hergenrother, P. J.; Martin, S. F J. Am. Chem. Soc. 2013, “Synthesis of (±)-Actinophyllic Acid and Analogs:  Applications of Cascade Reactions and Diverted Total Synthesis.” 135,12984-12986.  DOI: 10.1021/ja4070206

 

4. Parkinson, E.I.; Bair, J.S.; Cismesia, M. Hergenrother, P.J. ACS Chem. Biol. 2013, “Efficient NQO1 Substrates are Potent and Selective Anticancer Agents.” 8, 2173-2183, DOI: 10.1021/cb4005832

 

3. Huang, X.; Dong, Y.; Bey, E.A.; Kilgore, J.A.; Bair, J.S.; Li, L.; Patel, M.; Parkinson, E.I.; Wang, Y.; Williams, N.S.; Gao, J.; Hergenrother, P.J.; Boothman, D.A. Cancer Res. 2012, “An NQO1 Substrate with Potent Antitumor Activity that Selectively Kills by PARP1-Induced Programmed Necrosis.” 72, 3038-3047, DOI: 10.1158/0008-5472.CAN-11-3135.

 

2. Parkinson, E.I.; Hergenrother, P.J. ChemMedChem. 2011, “Runaway ROS as a Selective Anticancer Strategy.” 6, 1957-1959, DOI: 10.1002/cmdc.201100381.

 

1. Parkinson, E.I.; Hatfield, J.M.; Tsurkan, L.; Hyatt, J.L.; Edwards, C.C.; Hicks, L.D.; Yan, B.; Potter, P.M. Bioorg. Med. Chem. 2011, “Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.” 29, 4635-4643, DOI: 10.1016/j.bmc.2011.06.012.