Matt Hostetler
Ph.D. in Chemistry
Purdue University
Postdoctoral Associate
2018 - present
Parkinson Lab
15. Noah M. Moriarty, Annaleigh M. Benton, Lauren E. Gartenhaus, Andrew R. Nelson, Haley A. Harper, Carli J. McMahan, Bennett D. Elzey, Jason A. Hanna*, and Elizabeth I. Parkinson* "Design, Synthesis, and Evaluation of Trihalomethyl Ketone Derivatives of Neocarzilin A as Improved Antimetastatic Agents" ACS Bio & Med Chem Au. 2024, ASAP, https://doi.org/10.1021/acsbiomedchemau.4c00087
14. Samantha Nelson and Elizabeth I. Parkinson* "Synthetic-bioinformatic natural product-inspired peptides" Nat. Prod. Rep. 2024, ASAP, https://doi.org/10.1039/D4NP00043A
13. Weimao Zhong#, Zachary L. Budimir#, Lucas O. Johnson, Elizabeth I. Parkinson*, Vinayak Agarwal*. "Activity and Biocatalytic Potential of an Indolylamide Generating Thioesterase" Org. Lett. 2024, ASAP, https://doi.org/10.1021/acs.orglett.4c03648
12. Annaleigh Benton, Noah M. Moriarty, Emma Terwilliger, Bozhi Liu, Ant Murphy, Hannah Maluvac, Mae Shu, Lauren E. Gartenhaus, Nimod D. Janson, Claire M. Pfeffer, Sagar M. Utturkar, Elizabeth I. Parkinson, Nadia A. Lanman, Jason A. Hanna* "miR-497 target gene regulatory network in angiosarcoma" Mol Cancer Res. 2024, ASAP, https://doi.org/10.1158/1541-7786.MCR-23-1075
11. César Aguilar, Amir Alwali, Madeline Mair, Lorena Rodriguez-Orduña, Haydeé Contreras-Peruyero, Ramya Modi, Carson Roberts, Nelly Sélem-Mojica, Cuauhtemoc Licona-Cassani, and Elizabeth I. Parkinson* "Actinomycetota bioprospecting from ore-forming environments" Microbial Genomics. 2024, 10, 10:001253. https://doi.org/10.1099/mgen.0.001253
10. Alyssa S. Eggly, Namuunzul Otgontseren, Carson B. Roberts, Amir Y. Alwali, Haylie E. Hennigan, and Elizabeth I. Parkinson* "A Diels–Alder probe for discovery of natural products containing furan moieties" Beilstein J. Org. Chem. 2024, 20, 1001-1010. https://doi.org/10.3762/bjoc.20.88
9. Amir Y Alwali, Diane Santos, César Aguilar, Audrey Birch, Lorena Rodriguez-Orduña, Carson B Roberts, Ramya Modi, Cuauhtemoc Licona-Cassani, Elizabeth I Parkinson* "Discovery of Streptomyces species CS-62, a novel producer of the Acinetobacter baumannii selective antibiotic factumycin" J. Ind. Microbiol. Biotechnol. ASAP. https://doi.org/10.1093/jimb/kuae014
8. Budimir, Z.L.; Patel, R.S.; Eggly, A.; Evans, C.N.; Rondon-Cordero, H.M.; Adams, J.J.; Das, C.; Parkinson, E.I.* "Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase" Nature Chem. Biol. 2024, 20, 120–128. https://doi.org/10.1038/s41589-023-01495-z
7. Nelson, S.; Harris, T.J.; Muli, C.S.; Maresh, M.E.; Baker, B.; Smith, C.; Neumann, C.; Trader, D.J.; Parkinson, E.I.* "Discovery and Development of Cyclic Peptide Proteasome Stimulators ChemBioChem. 2024, 25, e202300671. https://doi.org/10.1002/cbic.202300671
6. Alwali, A.Y.; Parkinson, E.I.* "Small Molecule Inducers of Actinobacteria Natural Product Biosynthesis" J. Ind. Microbiol. Biotechnol. 2023, 50, kuad019. https://doi.org/10.1093/jimb/kuad019
5. Wilbanks, L.E.; Hennigan, H.E.; Martinez-Brokaw, C.D.; Lakkis, H.; Thormann, S.; Eggly, A.S.; Buechel, G.; Parkinson, E.I.* "Synthesis of Gamma-Butyrolactone Hormones Enables Understanding of Natural Product Induction" ACS Chem. Biol. 2023, 18, 1624-1631.. https://doi.org/10.1021/acschembio.3c00241
4. Modi, R.; McKee, N.; Zhang, N.; Alwali, A.; Nelson, S.; Lohar, A.; Ostafe, R.; Zhang, D.D.; Parkinson, E.I* "Stapled Peptides as Direct Inhibitors of Nrf2-sMAF Transcription Factors" J. Med. Chem. 2023, 66, 6184–6192. https://doi.org/10.1021/acs.jmedchem.2c02037
3. Parkinson, E.I.*; Lakkis, H.G.; Alwali, A.A.; Metcalf, M.E.M.; Modi, R.; Metcalf, W.W.* "An Unusual Oxidative Rearrangement Catalyzed by a Divergent Member of the 2-Oxoglutarate-Dependent Dioxygenase Superfamily during Biosynthesis of Dehydrofosmidomycin" Angew. Chem. Int. Ed. 2022, 61(30):e202206173. https://doi.org/10.1002/anie.202206173
2. Hostetler, M.A.; Smith, C.; Nelson, S.; Budimir, Z.; Modi, R.; Woolsey, I.; Frerk, A.; Baker, B.; Gantt, J., Parkinson, E.I.* "Synthetic Natural Product Inspired Cyclic Peptides. ACS Chem. Biol. 2021, 16, 11, 2604–2611. https://doi.org/10.1021/acschembio.1c00641
1. Schorn MA, Verhoeven S, Ridder L, Huber F, Acharya DD, Aksenov AA, Aleti G, Moghaddam JA, Aron AT, Aziz S, Bauermeister A, Bauman KD, Baunach M, Beemelmanns C, Beman JM, Berlanga-Clavero MV, Blacutt AA, Bode HB, Boullie A, Brejnrod A, Bugni TS, Calteau A, Cao L, Carrión VJ, Castelo-Branco R, Chanana S, Chase AB, Chevrette MG, Costa-Lotufo LV, Crawford JM, Currie CR, Cuypers B, Dang T, de Rond T, Demko AM, Dittmann E, Du C, Drozd C, Dujardin JC, Dutton RJ, Edlund A, Fewer DP, Garg N, Gauglitz JM, Gentry EC, Gerwick L, Glukhov E, Gross H, Gugger M, Guillén Matus DG, Helfrich EJN, Hempel BF, Hur JS, Iorio M, Jensen PR, Kang KB, Kaysser L, Kelleher NL, Kim CS, Kim KH, Koester I, König GM, Leao T, Lee SR, Lee YY, Li X, Little JC, Maloney KN, Männle D, Martin H C, McAvoy AC, Metcalf WW, Mohimani H, Molina-Santiago C, Moore BS, Mullowney MW, Muskat M, Nothias LF, O'Neill EC, Parkinson EI, Petras D, Piel J, Pierce EC, Pires K, Reher R, Romero D, Roper MC, Rust M, Saad H, Saenz C, Sanchez LM, Sørensen SJ, Sosio M, Süssmuth RD, Sweeney D, Tahlan K, Thomson RJ, Tobias NJ, Trindade-Silva AE, van Wezel GP, Wang M, Weldon KC, Zhang F, Ziemert N, Duncan KR, Crüsemann M, Rogers S, Dorrestein PC, Medema MH, van der Hooft JJJ. “A community resource for paired genomic and metabolomic data mining.” Nat Chem Biol. 2021. 17, 363-368. https://doi.org/10.1038/s41589-020-00724-z
Prior to Parkinson Lab